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https://doi.org/10.1152/physrev.00044.2018. Announcement of the latest impact factors from the Journal Citation Reports for the Life Sciences. Physical Review is an American peer-reviewed scientific journal established in 1893 by Edward Nichols.It publishes original research as well as scientific and literature reviews on all aspects of physics.It is published by the American Physical Society (APS). https://doi.org/10.1152/physrev.00003.2019, https://doi.org/10.1152/physrev.00018.2019. Impact Factor: 5.440 ℹ Impact Factor: 2019: 5.440 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging. With the employment of a taste-avoidance paradigm in rats, this phenomenon was rediscovered 45 yr ago as one of the most fascinating examples of the reciprocal functional interaction between behavior, the brain, and peripheral immune functions, and it established psychoneuroimmunology as a new research field. APS members work at the frontiers of science to advance our understanding of life and health. Over the past several decades a large amount of data have established that glial cells, the main cell population in the brain, dynamically interact with neurons and thus impact their activity and survival. In particular, FFAR1 (GPR40) and FFAR4 (GPR120) are activated by long-chain saturated and unsaturated fatty acids, while FFAR3 (GPR41) and FFAR2 (GPR43) are activated by SCFAs, mainly acetate, butyrate, and propionate. Physiological Reviews provides state of the art coverage of timely issues in the physiological and biomedical sciences. Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantially contribute to the progression of the tumor. This suggests that the early distal convoluted tubule (DCT) is a K+ sensor that can modify sodium (Na+) delivery to downstream segments to promote or limit K+ secretion. Physiological Reports is an online, open access monthly journal that publishes peer-reviewed research across all areas of basic and translational physiology and allied disciplines.Case reports are acceptable, so long as they have a physiological focus, but Physiological Reports does not publish clinical trials.For further information, see the journal's full scope statement. 5.893 Impact Factor. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. Annual Reviews Rankings in Journal Citation Reports (Clarivate Analytics) 2020 Release of Journal Citation Reports. About Physiological Reviews. The observation that associative learning processes can modify peripheral immune functions was first reported and investigated by Ivan Petrovic Pavlov and his co-workers. One typical feature of glia is their marked expression of several connexins, the membrane proteins forming intercellular gap junction channels and hemichannels. https://doi.org/10.1152/physrev.00034.2019. The impact factor is one of these; it is a measure of the frequency with which the “average article” in a journal has been cited in a particular year or period. This review aims to summarize our current understanding of two key aspects of ribbon synapses: 1) their mechanisms of exocytosis and endocytosis and 2) their molecular anatomy and physiology. Editor in Chief, Michael Thoennessen, celebrates the 50th anniversary of Physical Review A, B, C, and D. The year 2020 marks Physical Review C ’s 50 th anniversary. The final section summarizes the rapidly growing evidence indicating a prominent role of the extracellular nucleotide/P2 receptor system in the pathophysiology of the kidney and aims to identify potential therapeutic opportunities, including hypertension, lithium-induced nephropathy, polycystic kidney disease, and kidney inflammation. Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Besides the direct impacts of the disease, a plethora of indirect consequences of the pandemic adversely affect maternal health, including reduced access to reproductive health services, increased mental health strain, and increased socioeconomic deprivation. https://doi.org/10.1152/physrev.00001.2019. Examples include trigeminal neuralgia, painful polyneuropathy, postherpetic neuralgia, and central poststroke pain. American Physical Society (APS) is a non-profit membership organization working to advance and diffuse the knowledge of physics through its outstanding research journals, scientific meetings, and education, outreach, advocacy and international activities. The 2020 Edition of the Journal Citation Reports® (JCR) published by Clarivate Analytics provides a combination of impact and influence … Attention is paid to effects on the cortical vasculature and intraglomerular structures, autoregulation of renal blood flow, tubuloglomerular feedback, and the control of medullary blood flow. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs. ... Review article Full text access Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Chronic, pathological pain remains a global health problem and a challenge to basic and clinical sciences. Physiological changes during pregnancy have a significant impact on the immune system, respiratory system, cardiovascular function, and coagulation. K+-induced natriuresis through NCC offers a novel explanation for the antihypertensive effects of a high-K+ diet. Publication Fee Our journal is turning from Page Charges to the Article Processing Charges (APCs) for papers which will be published in 2021. The 2020 Edition of the Journal Citation Reports® (JCR) published by Clarivate Analytics provides a combination of impact and influence … Phosphate plays a central role in the process of mineralization, normal serum levels being associated with appropriate bone mineralization, while high and low serum levels are associated with soft tissue calcification. Physiological Reviews Jan 2018 1-557. MGO is mainly formed as a byproduct of glycolysis and, under physiological circumstances, detoxified by the glyoxalase system. https://doi.org/10.1152/physrev.00036.2019, The heart is vital for biological function in almost all chordates, including humans. As the premier journal in the interrelated areas of statistical, nonlinear, biological, and soft matter physics, PRE covers recent developments in complex fluids, polymers, liquid crystals, and granular materials. If it stops, so does life. The phenomenon of behaviorally conditioned immunological and neuroendocrine functions has been investigated for the past 100 yr. In this review, we discuss the mechanisms by which mammals sense changes in O2 and CO2 and elicit adaptive responses to maintain homeostasis. In the current review, we present evidence for, and implications of, MEC in health and disease in human; summarize our understanding of MEC effects gained from whole animal, organ, tissue, and cell studies; identify potential molecular mediators of MEC responses; and demonstrate the power of computational modeling in developing a more comprehensive understanding of ‟what makes the heart tick.ˮ, https://doi.org/10.1152/physrev.00043.2018. The journal's first managing editor, who served to his death in 1946, was Dr. Donald R. 2019 Impact Factor. Further research is essential to understand the function, regulation, and coordination of the various phosphate transporters, both the ones described in this review and the phosphate transporters involved in intracellular transport. On this occasion, the editors launch a collection of select papers. Their work later fell into oblivion, also because so little was known about the immune system’s function and even less about the underlying mechanisms of how learning, a central nervous system activity, could affect peripheral immune responses. We attempt to provide a framework for such different functions, for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities. The review summarizes recent breakthroughs and insights on structure-function properties in nociceptive circuits and higher order sub-neocortical modulatory circuits involved in aversion, learning, reward, and mood and their modulation by endogenous GABAergic inhibition, noradrenergic, cholinergic, dopaminergic, serotonergic, and peptidergic pathways. K+ sensing is mediated by the basolateral K+ channels Kir4.1/5.1, a capacity that the DCT likely shares with other nephron segments. See Cummins, Eoin P., Moritz J. Strowitzki, and Cormac T. Taylor. Publishing during COVID-19 Amongst the many significant challenges during the COVID-19 pandemic is the disruption to … Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. In this article, we discuss the molecular basis of DNA targeting tools and review the potential of these new technologies before we summarize how these have already been used for the manipulation of cellular states and hypothesize about future applications. Copyright © 2020 the American Physiological Society, Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy, Sensory Processing at Ribbon Synapses in the Retina and the Cochlea, SIRT6, a Mammalian Deacylase with Multitasking Abilities, Free Fatty Acid Receptors in Health and Disease, Extracellular Nucleotides and P2 Receptors in Renal Function, Current Principles of Motor Control, with Special Reference to Vertebrate Locomotion, Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis, Pavlovian Conditioning of Immunological and Neuroendocrine Functions, Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases, Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals, American Journal of Physiology-Cell Physiology, American Journal of Physiology-Endocrinology and Metabolism, American Journal of Physiology-Gastrointestinal and Liver Physiology, American Journal of Physiology-Heart and Circulatory Physiology, American Journal of Physiology-Lung Cellular and Molecular Physiology, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Journal of Physiology-Renal Physiology, American Journal of Physiology (1898-1976). These Milestone studies represent lasting contributions to physics by way of reporting significant discoveries, initiating new areas of research, or substantially enhancing the conceptual tools for making progress in the burgeoning field of condensed matter physics. Moreover, chronic pain involves diverse maladaptive plasticity processes, which have not been decoded mechanistically in terms of involvement of specific circuits and cause-effect relationships. Phosphate is an essential nutrient for life and is a critical component of bone formation, a major signaling molecule, and structural component of cell walls. https://doi.org/10.1152/physrev.00033.2018. Physical Review Fluids (PRFluids) is dedicated to publishing innovative research that will significantly advance the fundamental understanding of fluid dynamics. Here, we aim to cover all main aspects of this complex behavior, from the operation of the microcircuits in the spinal cord to the systems and behavioral levels and extend from mammalian locomotion to the basic undulatory movements of lamprey and fish. https://doi.org/10.1152/physrev.00024.2020. Thus, next to K+-induced aldosterone secretion, K+ sensing by renal epithelial cells represents a second feedback mechanism to control K+ balance. MGO and MGO-derived AGEs can impact on organs and tissues affecting their functions and structure. Much of the vital control of cardiac function occurs at the level of individual cardiac muscle cells, including acute beat-by-beat feedback from the local mechanical environment to electrical activity (as opposed to longer term changes in gene expression and functional or structural remodeling). Space is essential that endogenous levels are monitored and kept at appropriate concentrations maintain. 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