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atopic dermatitis review article

17/01/2021


We review existing and emerging evidence for fabric selection in patients with atopic dermatitis including cotton, wool, lyocell, silk, anionic, cellulosic/cellulose based, zinc oxide coated, citric acid coated, chitosan coated, silver coated, borage seed oil coated, ethylene vinyl, and polyurethane and offer practical suggestions for clothing and bedding choices. Atopic dermatitis (AD) is an inflammatory chronic condition that affects the skin of children and adults and has an important impact on the quality of life. Dupilumab (Dupixent®), a subcutaneously administered, fully human IgG4 monoclonal antibody directed against the IL (interleukin)-4 receptor α subunit, blocks the signalling of IL-4 and IL-13, two T helper cell type 2 cytokines implicated in the immunopathology of atopic dermatitis (AD). AU - Walker, C. AU - Craig, Timothy. NIH Explore the latest full-text research PDFs, articles, conference papers, preprints and more on ATOPIC DERMATITIS. Identify nonpharmacologic therapies for skin care in patients with AD.3. Atopic dermatitis (AD) is a common, chronic skin disorder that can significantly impact the quality of life of affected individuals as well as their families. Main outcome measures Incidence rate ratios of atopic dermatitis. 3 Close to three-quarters of cases obtain complete remission by age 16. Nonpharmacologic and pharmacologic interventions are discussed, with an emphasis on emerging treatments for AD. This paper gives an overview of the natural history, clinical features, … INTRODUCTION. Clin Rev Allergy Immunol. Participants 24 341 mother-child pairs. Andrea R. Waldman, MD* 2. T1 - Atopic dermatitis. Simulations were performed by running combinations of search terms in MEDLINE and EMBASE. The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial. Incidence of AD has increased 2- to 3-fold in industrialized nations, impacting approximately 15% to 20% of children and 1% to 3% of adults worldwide. It is postulated as the first manifestation of the “atopic march”—often … 1. The purpose of this learning activity is to provide information about the diagnosis and management of atopic dermatitis (AD). T1 - Atopic dermatitis. Study Selections. Atopic dermatitis, also known as atopic eczema, eczema, neurodermatitis and Besnier’s prurigo, 1 2 is a complex disease with variable clinical presentations, associations with other atopic diseases and clinical courses. Purpose of the review: To summarize recent topics on type 2 signatures in atopic dermatitis (AD). Many patients present at the subspecialist level grossly undertreated with topical medications and emollients. Atopic dermatitis (AD) is a chronic inflammatory skin condition involving complex interactions between immunologic, hereditary, and environmental influences. Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease. Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. To cite this article. Information on atopic dermatitis, infectious diseases occurring before 6 months of age, number of siblings, early day care, pet keeping, farm residence, and background factors was collected in telephone interviews. Although topical corticosteroids are considered to be the first-line agents, they can be associated with … General purpose: PY - 1999/3. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their impact on key outcome measures. 1. The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. 1,2 In North America, the prevalence ranges between 9.8% and 10.3% in children ages 6 to 7 and 6.5% and 9.4% in ages 13 to 14. Target audience:  |  Jeremy Udkoff, MA* 4. PY - 1999/3. Objective. eCollection 2020. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. Recommended articles Citing articles (0) Am J Manag Care. A review of the literature reveals that chromosome 6, 11, 14, and 13 may be imprinted in atopic dermatitis. Clin Rev Allergy Immunol. It can be frustrating for pediatric patients, parents, and health care providers alike. ABSTRACT: Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disease that affects both children and adults. Jenna F. Borok, BS* 5. 1 Over the last 30 years, the prevalence of AD has risen globally, affecting ∼20% of children and 3% of adults worldwide. After completing this continuing education activity, you should be able to:1. A rare skin infection in atopic dermatitis: A case report. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Int J Dermatol. A total of 22% of patients seen in pediatric dermatology clinics have atopic dermatitis. Dermatol Clin. 2016;51(3):329-337. doi: 10.1007/s12016-016-8548-5. 2017 Jul;35(3):283-289. doi: 10.1016/j.det.2017.02.002. ABSTRACT: Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disease that affects both children and adults. Atopic dermatitis is a chronic relapsing skin condition associated with dry skin and itching. Healthcare providers play an important role in the management of AD to improve economic and clinical outcomes. MEDLINE and EMBASE were searched for SR related to AD. eCollection 2020 Dec. Foulon M, Robbe-Saule M, Manry J, Esnault L, Boucaud Y, Alcaïs A, Malloci M, Fanton d'Andon M, Beauvais T, Labarriere N, Jeannin P, Abel L, Saint-André JP, Croué A, Delneste Y, Boneca IG, Marsollier L, Marion E. PLoS Pathog. The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. Article Page Abstract. Epub 2016 Sep 8. International study of epidemiology and geographic variability in prevalence of AD has been conducted in three phases with 1,000,000 subjects in the third phase study. 24 - N. 22 Pages: 11804-11809 DOI: 10.26355/eurrev_202011_23837 Epub 2017 Apr 22. This systematic review uses data from randomized clinical trials obtained via MEDLINE, Embase, Cochrane Central Register, and ClinicalTrials.gov to investigate the inclusion of older adults in studies pertaining to systemic medication used in the treatment of atopic dermatitis. Key Points. 2004 Oct;16(10):451-4. doi: 10.1111/j.1745-7599.2004.tb00423.x. The terms used for the search were ‘prebiotic’, ‘probiotic’, ‘atopic dermatitis’, ‘Severity Scoring of Atopic Dermatitis’, and ‘SCORAD’. 115. Although topical corticosteroids are considered to be the first-line agents, they can be associated with cutaneous and systemic adverse effects. Patients with AD are increasingly turning to Chinese medicine. Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease characterized by pruritus, erythema, scaling, edema, and inflammatory eczematous eruptions that usually begin early in life .AD is a major global public health problem, affecting 1%–20% of people worldwide, with a prevalence of about 1%–3% in adults and 10%–20% in children . ... systematic review. This article reviews the epidemiology, burden of disease, pathophysiology, and diagnostic criteria important for early diagnosis and treatment. Would you like email updates of new search results? J Invest Dermatol. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Filaggrin plays an important role in the development of AD and allergic disease. 1 Over the last 30 years, the prevalence of AD has risen globally, affecting ∼20% of children and 3% of adults worldwide. Treatment should be directed at limiting itching, repairing the skin and decreasing inflammation when necessary. COVID-19 is an emerging, rapidly evolving situation. 2004 Oct;43(10):739-44. doi: 10.1111/j.1365-4632.2004.02360.x. Ong PY, Leung DY. N2 - Atopic dermatitis is a common disease, causing significant morbidity. Explain the pharmacologic management of AD. IMMUNOLOGY | REVIEW ARTICLE Pathogenesis of atopic dermatitis: A short review Gyohei Egawa 1* and Wolfgang Weninger ,2,3* Abstract: Atopic dermatitis (AD) is the most common inflammatory skin disease in children, may persist into adulthood, and is difficult to treat. Atopic dermatitis (AD) (syn. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Jusleen Ahluwalia, MD* 3. Setting Danish national birth cohort. Epub 2017 Oct 7. Lawrence F. Eichenfield, MD* 1. Atopic dermatitis is a common inflammatory skin condition characterized by relapsing eczematous lesions in a typical distribution. Introduction. Atopic dermatitis (AD), also known as atopic eczema is a common chronic or recurrent inflammatory skin disorder with a significant social and economic impact worldwide, affecting 2.1–4.9% of adult population, and 15–20% of children (1,2).An increasing prevalence of AD has been reported, especially in low-income countries (). Atopic dermatitis is a common inflammatory skin condition characterized by relapsing eczematous lesions in a typical distribution. Atopic dermatitis (AD) is a bothersome and common skin disease affecting ∼10.7% of children in the United States. Article Page Abstract. Recall the diagnostic process of AD.2. Purpose of review . Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Y1 - 1999/3. 2020 Dec;8(6):e00679. Atopic dermatitis (AD) is a chronic, itching skin disease, and conventional therapies offer inadequate symptom management. It is a disease caused by the combination of genetic predisposition, immune dysregulation, and skin barrier defect. Diagnosis and Management of Atopic Dermatitis: A Review. In recent years, emerging evidence suggests oxidative stress may play an important role in many skin diseases and skin aging, possibly including AD.  |  This review includes all the articles published in PubMed, Scopus, Embase and Cochrane databases until 05.06.2018. 1 It affects approximately 20% of children and 3–10% of adults, 2 with mean lifetime prevalence increasing in recent decades. Atopic dermatitis (AD) is a common, chronic skin disorder that can significantly impact the quality of life of affected individuals as well as their families. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Recent data in both ex- 5-8 The mechanisms underlying bacterial infection in AD are multifactorial and include both host and bacterial factors. We performed a PubMed literature review consisting mainly of studies relating to filaggrin in the last 5 years. There was an increase … Pathophysiology and Management of Mild to Moderate Pediatric Atopic Dermatitis. R.T. Hernández-Rodríguez, L.M. The current and novel therapies for the treatment of atopic dermatitis will be discussed. IMMUNOLOGY | REVIEW ARTICLE Pathogenesis of atopic dermatitis: A short review Gyohei Egawa 1* and Wolfgang Weninger ,2,3* Abstract: Atopic dermatitis (AD) is the most common inflammatory skin disease in children, may persist into adulthood, and is difficult to treat. Eckert L, Gupta S, Amand C, Gadkari A, Mahajan P, Gelfand JM. J Am Acad Dermatol. eCollection 2021 Jan. Mansour NO, Mohamed AA, Hussein M, Eldemiry E, Daifalla A, Hassanin S, Nassar N, Ghaith D, Mohamed Salah E. Pharmacol Res Perspect. Lesional skin of AD expresses increased levels of IL-4 and IL-13. NLM It is characterized by acute flare-ups of pruritic lesions over dry skin Atopic dermatitis is a subset of the broad classification of eczema. Sun B, Wu L, Wu Y, Zhang C, Qin L, Hayashi M, Kudo M, Gao M, Liu T. Front Pharmacol. Recently, numerous clinical investigations have evolved our understanding of the pathogenesis of atopic dermatitis, and the American Academy of Dermatology released new atopic dermatitis guidelines in 2014. This article provides an overview of the epidemiology, clinical features, pathophysiology, complications, and specific investigations of atopic dermatitis. A large number of studies investigating the correlation between severity of atopic dermatitis and various biomarkers have been published over the past decades. Adv Skin Wound Care. 2020 Mar 25;8(2):70. doi: 10.3390/healthcare8020070. Atopic dermatitis (AD), also known as atopic eczema, is a chronic relapsing inflammatory skin condition. 2017 Jan;137(1):26-30. doi: 10.1016/j.jid.2016.07.012. 1, 2 Current understanding of AD pathogenesis points towards a sophisticated interplay between genetic and environmental factors. Canine atopic dermatitis is a model of human atopic dermatitis. Public Health Burden and Epidemiology of Atopic Dermatitis. doi: 10.1016/j.pedhc.2017.10.002. This skin condition significantly decreases quality of life in not only patients, but in their families as well. Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. Background: Atopic dermatitis is a chronic inflammatory skin condition that affects up to 20% of children and 3% of adults globally. Results. Trending Now: Shifts and Gaps in Atopic Dermatitis Management by Derm and Non-Derm Physicians. The aim of this review was to identify, evaluate and synthesize the evidence examining the correlation of biomarkers with disease severity in atopic dermatitis patients, something that has not been performed previously. Atopic dermatitis: an overview for the nurse practitioner.  |  Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Abstract: 115. Bacterial and viral infections in atopic dermatitis: a comprehensive review. AD has a wide-ranging impact on a patient's quality of life and the burden from direct and indirect costs (approximately $37.7 billion in out-of-pocket costs) is shared by the families and caregivers of patients with AD. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Atopic dermatitis (AD) is one of the most common and debilitating chronic inflammatory skin diseases, often greatly affecting physical, economical, and psychological quality of life (QoL). 2020 Dec 18;16(12):e1009107. Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. eCollection 2020 Dec. JAAD Case Rep. 2020 Nov 5;7:54-56. doi: 10.1016/j.jdcr.2020.10.036.  |  J Pediatr Health Care. Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. Adv Exp Med Biol. This review aims to identify previously reported phenotypes of atopic dermatitis, the features used to define them and any characteristics or clinical outcomes significantly associated with them. T2 - a clinical review for the primary care physician. Amezcua-Guerra The potential role of microRNAs as biomarkers in atopic dermatitis: a systematic review. Recent findings: Therapeutic success of anti-IL-4 receptor antibody dupilumab does suggest that type 2 cytokines IL-4 and IL-13 have pivotal roles in the pathogenesis of AD. Question What are the prevalence, origin, and effect on treatment adherence of topical corticosteroid phobia in atopic dermatitis?. Background. AD has a wide-ranging impact on a patient's … The study by Eric Simpson and colleagues1 regarding the safety and efficacy of abrocitinib monotherapy in adolescents and adults with moderate-to-severe atopic dermatitis concluded that daily oral abrocitinib is effective and well tolerated in adolescents and adults with atopic dermatitis.1 AD affects adults and children with worldwide prevalence rates of 1‐20%. This systematic review uses data from randomized clinical trials obtained via MEDLINE, Embase, Cochrane Central Register, and ClinicalTrials.gov to investigate the inclusion of older adults in studies pertaining to systemic medication used in the treatment of atopic dermatitis. Although the pathogenesis of the disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune dysregulation. 2017;1027:1-10. doi: 10.1007/978-3-319-64804-0_1. Learning objectives/outcomes: Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. And while adults 60 and older tend to have a distinct atopic dermatitis presentation and important comorbidities, dermatologists treating these patients find lacking evidence on how to diagnose and best treat atopic dermatitis in the elderly, according to a review published March 21, 2019 in the British Journal of Dermatology. Atopic dermatitis (AD), also known as atopic eczema, is a chronic relapsing inflammatory skin condition. Back by popular demand, Dr. Steven Feldman, Professor of Dermatology, Pathology and Public Health joins host Dr. Adam Friedman from GW School of Medicine to review his recent database dive entitled “Trends in Atopic Dermatitis Management: Comparison of 1990-1997 to 2003-2012.” Introduction. NLM Y1 - 1999/3. Balancing safety concerns with efficacious treatment is of particular importance in the pediatric population. Wh… Atopic dermatitis (AD) is a chronic pruritic skin disorder affecting many people especially young children. Current epidemiology of atopic dermatitis in south-eastern Nigeria. doi: 10.1002/prp2.679. Treatment strategies need to be individualized with a strong emphasis on patient education and self-management strategies to optimize outcomes and reduce unnecessary costs associated with the management of AD. Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disease that affects both children and adults. doi: 10.1371/journal.ppat.1009107. Introduction. 4 However, adult prevalence remains around 10%. 1-4 Staphylococcus aureus is the most common infectious organism, although beta‐haemolytic streptococci may also be involved. This review includes all the articles published in PubMed, Scopus, Embase and Cochrane databases until 05.06.2018. T2 - a clinical review for the primary care physician. This site needs JavaScript to work properly. N2 - Atopic dermatitis is a common disease, causing significant morbidity. Atopic dermatitis is not always easily manageable and every physician should be familiar with the fundamental aspects of treatment. Lubricants, antihistamines and topical corticosteroids are the mainstays of therapy. Atopic dermatitis (AD) is a common and chronic inflammatory skin disorder. This article provides an overview of the epidemiology, clinical features, pathophysiology, complications, and specific investigations of atopic dermatitis. 2017 Jun;23(8 Suppl):S115-S123. This site needs JavaScript to work properly.  |  Introduction. Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with a frequently remitting and relapsing course. Scratching the Surface: A Review of Dermatitis. Atopic dermatitis is a common, potentially debilitating condition that can compromise quality of life. USA.gov. atopic eczema) is a chronic inflammatory skin condition, affecting up to 20% of children and 5%‐10% of adults. Atopic dermatitis, one of the most common skin disorders in young children, has a prevalence of 10% to 20% in the first decade of life. Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology. Herbs are widely used in the treatment of atopic dermatitis (AD) in Eastern Asian countries, and certain herbs regarded have anti-inflammatory properties that can help with AD. Atopic dermatitis affects an estimated 2% to 3% of elderly people. The aetiology of atopic dermatitis is unknown, but the recent discovery of filaggrin mutations holds promise that the progression of atopic dermatitis to asthma in later childhood may be halted. The burden of atopic dermatitis in US adults: Health care resource utilization data from the 2013 National Health and Wellness Survey. Malara G, Trifirò C, Bartolotta A, Conte M, Denisi P. Clin Case Rep. 2020 Sep 14;8(12):2945-2947. doi: 10.1002/ccr3.3167. Clipboard, Search History, and several other advanced features are temporarily unavailable. Although it most often starts in infancy and affects two of ten children, it is also highly prevalent in adults. Bacterial and viral infections in atopic dermatitis: a comprehensive review. New insights related to the genetic, immunologic, and environmental impacts of AD have created new treatment opportunities. A total of 22% of patients seen in pediatric dermatology clinics have atopic dermatitis. It is a chronic illness that requires a multifaceted treatment strategy in the setting of limited therapeutic options. Psoriatic disease may be related to imprinting effects on chromosome 6 for psoriasis and 16 for psoriatic arthritis. 2018 Jan;78(1):54-61.e1. Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. NIH 2018 Mar-Apr;32(2):S2-S12. Atopic dermatitis (AD), or childhood eczema, is a chronic skin disorder that often occurs in association with allergic rhinitis and asthma (known as the atopic triad). Diagnosis and Management of Atopic Dermatitis: A Review Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disease that affects both children and adults. Atopic dermatitis is an inflammatory skin disease with early onset and with a lifetime prevalence of approximately 20%.  |  The assessment will be publicly discussed during a meeting of the New England CEPAC ( New England CEPAC ) in July 2021, where the independent evidence review panel will deliberate and vote on evidence presented in … Incidence of AD has increased 2- to 3-fold in industrialized nations, impacting approximately 15% to 20% of children and 1% to 3% of adults worldwide. This review provides an outline and discussion of clinical and other phenotypes of atopic dermatitis in dogs to better understand this disease in both dogs and humans. Maliyar K, Sibbald C, Pope E, Gary Sibbald R. Adv Skin Wound Care. Its most frequent symptom is pruritus. AU - Walker, C. AU - Craig, Timothy. We selected articles that were found in PubMed using the search terms filaggrin, atopic dermatitis, skin barrier, and atopy. Introduction. Background: Atopic dermatitis is a chronic inflammatory skin condition that affects up to 20% of children and 3% of adults globally. The study by Eric Simpson and colleagues1 regarding the safety and efficacy of abrocitinib monotherapy in adolescents and adults with moderate-to-severe atopic dermatitis concluded that daily oral abrocitinib is effective and well tolerated in adolescents and adults with atopic dermatitis.1 Although the pathogenesis of the disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune dysregulation. Introduction Atopic dermatitis, also referred to as atopic eczema, infantile eczema, allergic eczema, disseminated neurodermatitis, and prurigo Besnier, is a common and important cause of morbidity in children of all ages. HHS Please enable it to take advantage of the complete set of features! 2020 Sep 4;11:568032. doi: 10.3389/fphar.2020.568032. 2019 Dec;32(12):542-549. doi: 10.1097/01.ASW.0000604184.92824.43. Introduction Atopic dermatitis, also referred to as atopic eczema, infantile eczema, allergic eczema, disseminated neurodermatitis, and prurigo Besnier, is a common and important cause of morbidity in children of all ages. Patients with atopic dermatitis (AD; also known as ‘atopic eczema’) have an increased risk of recurrent skin infections. Findings In this systematic review, the prevalence of topical corticosteroid phobia ranged from 21.0% to 83.7%; compared with patients without phobia, patients reporting phobia had higher nonadherence rates. 3 Traditionally, atopic dermatitis was characterised as an allergic disease of childhood, but it is now well-established that non-allergic forms exist and patients have been … Bekić S, Martinek V, Talapko J, Majnarić L, Vasilj Mihaljević M, Škrlec I. Healthcare (Basel). Eur Rev Med Pharmacol Sci Year: 2020 Vol. Attempts to relieve the itch by scratching simply worsen the rash, creating a vicious circle. doi: 10.1016/j.jaad.2017.08.002. Would you like email updates of new search results? 2018 Dec;31(12):538-550. doi: 10.1097/01.ASW.0000547414.38888.8d. In this article, we review the literature and data regarding the use of probiotics, both by oral administration and topical application, for the treatment of atopic dermatitis. This article provides an overview of the epidemiology, clinical features, pathophysiology, complications, and specific investigations of atopic dermatitis. Skin Wound care, Qureshi AA, Majnarić L, Vasilj Mihaljević M, Škrlec Healthcare. In atopic dermatitis emphasis on emerging treatments for AD are multifactorial and include both host and factors. It can be frustrating for pediatric patients, parents, and conventional therapies inadequate... 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